Medwave se preocupa por su privacidad y la seguridad de sus datos personales. Palma Sanchez et al. Un estudio en pacientes mexicanos Araiza-Casillas et al. Desde las recomendaciones de , se mencionaba la preferencia por realizar estudios que no dependan de la respuesta del paciente. Este problema fue resuelto con el desarrollo del electroretinograma multifocal que, aunque fue descrito inicialmente en por Sutter et al.

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Antimalarials are long-standing drugs that have been used since the nineteenth century for the treatment of skin rashes and lesions in lupus and rheumatoid arthritis.

In recent decades, their use in these disorders has been consolidated, and new mechanisms of action have been incorporated, broadening the therapeutic perspectives of these drugs. Antimalarials are the treatment of choice in mild and moderate manifestations of systemic lupus erythematosus and are established as part of combined therapy in rheumatoid arthritis. They have been shown to have beneficial effects on atherosclerosis, as well as a possible role in the early treatment of antiphospholipid syndrome.

This review aims to provide an update on the use of these drugs in rheumatology and to discuss their toxicity profile.. ISSN: X. Read this article in English.

Antimalarials: an update in rheumatic diseases. Descargar PDF. Autor para correspondencia. Hospital Universitario Puerta de Hierro. Palabras clave:. This review aims to provide an update on the use of these drugs in rheumatology and to discuss their toxicity profile. Key words:. Treatment of lupus erythematosus with mepacrine. Lancet, 2 , pp. Lupus, 5 , pp. S2-S3 Medline. Is there a role for quinacrina Atabrine in the new millennium. Lupus, 9 , pp. Toubi, I. Rosner, M. Rozenbaum, A.

Kessel, T. The benefit ofcombining hydroxychloroquine with quinacrine in the treatment of SLE patients. Scherbel, J. Harrison, M. Further observations on the use of 4-aminoquinoline compounds in patients with rheumatoid arthritis related diseases. Cleve Clin Q, 25 , pp. Pharmacokinetics of hydroxychloroquine and chloroquine during treatment of rheumatic diseases.

SS15 Medline. Munster, J. Gibbs, D. Shen, B. Baethge, G. Botstein, J. Caldwell, et al. Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis. Arthritis Rheum, 46 , pp. Landewe, M. Vergouwen, S. Goeei The, A. Van Rijthoven, F. Breedveld, B. Antimalarial drug induced decrease in creatinine clearance. J Rheumatol, 22 , pp.

Rubin, H. Bernstein, N. Arch Ophthalmol, 70 , pp. Aponte, M. Petrelli, N. Von Dawson. Liver enzyme levels in artritis patirnts treated with long-term bolus methotrexate. Arthritis Rheum, 35 , pp. Jewell, D. Patients with cutaneous lupus erythematosus who smoke are less responsive to antimalarial treatment. J Am Acad Dermatol, 42 , pp. Pool, S. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages. J Cell Biol, 90 , pp. Mechanism of action of hydroxychloroquine as an antirheumatic drug.

Sem Arthritis Rheum, 23 , pp. Anti-malarial drugs: possible mechanisms of action in autoimmune disease and prospects for drugs development. S4-S10 Medline. Antimalarial drugs in the treatment of rheumatological diseases. J Rheumatol, 36 , pp. Bondeson, R. Gen Pharmac, 30 , pp. Murphy, J. Hawk, I. Hydroxychloroquine in polymorphic light eruption: a controlled trial with drug and visual sensitivity monitoring.

Brit J Dermatol, , pp. Wozniacka, A. Carter, D. Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit. Lupus, 11 , pp. Nguyen, J. Capra, R. Lupus, 7 , pp. Lafont, F. Chanussor, C. Dupuy, P. Lechene, D. Lairon, M. Charbonnier-Augeire, et al. Influence of acute injection of chloroquine on the biliary secretion of lipids and lysosomal enzyme on rats. Lipids, 19 , pp. Goldstein, G. Brunschede, M.

Inhibition of ptoteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A and Triton WR J Biol Chem, , pp. Chen, D. Chloroquine inhibits cyclization of squaleneoxide to lanosterol in mammalians cells. Beynen, A. Van der Moolen, M. Lipids, 16 , pp. Svenson, H. Lithell, R. Serum lipoprotein inactive rheumatoid arthritis and other chronic inflammatory arthritides.


antipalúdicos en el tratamiento de las enfermedades autoinmunes sistémicas y reumáticas

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