Key words:. Rev Gastroenterol Mex. J Clin Invest. Rev Med Chile.
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Individuals with the disease present with upper abdominal pain epigastric , at times accompanied by nausea, vomiting, loss of appetite , edema , weakness, and weight loss.
A small amount of gastrointestinal bleeding may occur, which is typically due to superficial mucosal erosions; large volume bleeding is rare. Inflammation is usually only modest, although some cases show marked intraepithelial lymphocytosis. Diffuse or patchy glandular atrophy, evident as hypoplasia of parietal and chief cells, is typical.
Endoscopy with deep mucosal biopsy and cytology is required to establish the diagnosis and exclude other entities that may present similarly. A non-diagnostic biopsy may lead to a surgically obtained full-thickness biopsy to exclude malignancy. Twenty-four-hour pH monitoring reveals hypochlorhydria or achlorhydria, and a chromium-labelled albumin test reveals increased GI protein loss. Several medications have been used in the treatment of the condition, with variable efficacy.
Such medications include: anticholinergic agents, prostaglandins , proton pump inhibitors , prednisone , and H2 receptor antagonists.
Anticholinergics decrease protein loss. A high-protein diet should be recommended to replace protein loss in patients with low levels of albumin in the blood hypoalbuminemia.
Any ulcers discovered during the evaluation should be treated in standard fashion. Severe disease with persistent and substantial protein loss despite cetuximab may require total removal of the stomach. Subtotal gastrectomy is performed by some; it may be associated with higher morbidity and mortality secondary to the difficulty in obtaining a patent and long-lasting anastomosis between normal and hyperplastic tissue.
In adults, there is no FDA approved treatment other than gastrectomy and a high-protein diet. Cetuximab is approved for compassionate use in the treatment of the disease. Pediatric cases are normally treated for symptoms with the disease clearing up in weeks to months. The average age of onset is 40 to 60 years, and men are affected more often than women. From Wikipedia, the free encyclopedia. J Clin Invest.
McGraw Hill. December Science Translational Medicine. ICD - 10 : K Orphanet : Diseases of the digestive system primarily K20—K93 , — Proctitis Radiation proctitis Proctalgia fugax Rectal prolapse Anismus.
Upper Hematemesis Melena Lower Hematochezia. Peritonitis Spontaneous bacterial peritonitis Hemoperitoneum Pneumoperitoneum. Categories : Stomach disorders. Namespaces Article Talk. Views Read Edit View history. Contribute Help Community portal Recent changes Upload file. In other projects Wikimedia Commons.
2016, Number 1
Individuals with the disease present with upper abdominal pain epigastric , at times accompanied by nausea, vomiting, loss of appetite , edema , weakness, and weight loss. A small amount of gastrointestinal bleeding may occur, which is typically due to superficial mucosal erosions; large volume bleeding is rare. Inflammation is usually only modest, although some cases show marked intraepithelial lymphocytosis. Diffuse or patchy glandular atrophy, evident as hypoplasia of parietal and chief cells, is typical.
Kaposi's sarcoma. Palabras clave: Enfermedad de Menetrier. Sarcoma de Kaposi. Its association with Kaposi's sarcoma KS in patients with human immunodeficiency virus HIV infection has only been reported in two patients by diSibio et al. Here we report one more case of this exotic association.