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Directory of Open Access Journals Sweden. Cassava leaves contain substances such as lignins and saponins that can present the hypolipidemic effect. However, a recent study has reported an increase in liver weight of rats fed diet containing cassava leaves flour CLF - Manihot esculenta Crantz cv. Thus, a further study of the effect of this flour on the hepatic parameters is necessary. The diets containing CLF showed no effects on the. Full Text Available -Abnormal liver function test with raised alanine aminotransferase ALT and raised aspartate aminotransferase AST are commonly seen in primary care setting.
Full Text Available Background Elevated aminotransferase levels are commonly associated with compromised hepatic integrity from various insults. In sickle cell disease, aspartate transaminase AST is also released via intravascular hemolysis. This study was done to determine the pattern of changes in AST and alanine transaminase ALT , in particular the AST:ALT ratio, and to relate these to the hemolytic state, which we consider to be more important than hepatic and cardiac dysfunction in some individuals with sickle cell disease.
Methods Serum aminotransferase levels were measured in subjects with sickle cell disease, as well as hemoglobin, reticulocytes, and lactate dehydrogenase. The AST:ALT ratio was designated as a hemolytic marker, and simple and multivariate regression analyses were carried out between this ratio and other hemolytic markers. In the subjects with sickle cell disease, the increases in AST levels were far higher than for ALT , supporting its release via intravascular hemolysis.
In Conclusion Regression analyses support the use of the AST:ALT ratio as a hemolytic marker, because it has an inverse association with the hemoglobin level. Whether in steady state or in crisis, provided hepatic and cardiac integrity has not been compromised, subjects with sickle cell disease would have higher AST levels due to the hemolytic nature of the condition.
Forty four biopsy proven diagnosed subjects of chronic viral hepatitis without cirrhosis of both sex were selected purposively. Aims The ratio of aspartate aminotransferase AST to alanine aminotransferase ALT is of great interest as a possible novel marker of metabolic syndrome.
However, longitudinal studies emphasizing the incremental predictive value of the AST-to-ALT ratio in diagnosing individuals at higher risk of developing metabolic syndrome are very scarce. Therefore, our study aimed to evaluate the AST-to-ALT ratio as an incremental predictor of new onset metabolic syndrome in a population-based cohort study.
Material and Methods The population-based cohort study included adults men and women aged 40—70 years, who participated from — baseline without metabolic syndrome and were followed up from — Metabolic syndrome was defined according to the harmonized definition of metabolic syndrome. Results During an average follow-up period of 2. The aim of this study was to define the reference intervals RIs for these enzymes in adults, paying attention to standardization of the methods used and careful selection of the reference population.
Three centers two in Italy and one in China measured their own freshly collected samples; one of these centers also measured frozen samples from the Nordic Countries RI Project and from a Turkish center. RIs were generated using non-parametric techniques from the results of individuals females and males, years old selected on the basis of the results of other laboratory tests and a specific questionnaire. AST results from the four regions Milan, Beijing, Bursa and Nordic Countries were statistically different, but these differences were too small to be clinically relevant.
Likewise, differences between the upper reference limits for genders was only 1. Interregional differences were not statistically significant for ALT , but partitioning was required due to significant gender differences.
The upper reference limits for GGT from the Nordic Country population were higher than those from the other three regions and results from this group were excluded from final calculations. Full Text Available Introduction: Lead is a natural element with toxic properties and is widespread in the environment.
Lead toxicity is associated with generation of reactive oxygen and nitrogen species and consumption of antioxidants elements vitamin E and C, glutathione, thioredoxin and lipoic acid, melatonin, carotenoids and natural flavonoids in the cell, and unbalancing oxidantsantioxidants levels. Materials and Methods: Experimental animals 49 male Mus musculus-swiss albino mice were separated into five different groups.
Blood samples were taken from the facial vein and used for transaminase analysis. Organ tissue was collected after euthanizing anaesthetized animals with neck dislocation technique. Results: The results showed that lead acetate treatment has caused significant elevation in the activity of AST group 2 and 3 and ALT group 3.
The levels of liver function tests LFTs are often used to assess liver injury and non-liver disease-related mortality. The prognostic significance of serum LFTs were determined by univariate and multivariate Cox hazard models. Material and Methods: A prospective experimental, observational, cross-sectional study was conducted in 30 children between 2 and 15 years old, from several Neoplastic Centers in Lima. Finally, coding and tabulation was performed.
Serum levels of AST were increased by Serum ALT values were increased in Moreover LDH levels were increased in Conclusions: The enzymatic tests LDH, AST , ALT and ALP are increased in children with ALL compared to normal values due to tumor lysis syndrome characterized by electrolyte abnormalities, and as a result of the massive destruction of tumor cells and rapid release of large amounts of intracellular elements.
The specimen was an orphan male calf, with cm of length and estimated weight of 49kg. It presented bad nutritional conditions and a shark bite on the right shoulder area. On the 16th the animal presented a right unilateral conjuntivitis, treated with Cloranphenicol oftalmic pomade until the end of its stay in the captive. During this period a total of six blood samples were collected, three for total blood counts and the others for the biochemistry determination of ALT , AST and creatinine.
According to the haematological analysis the seal developed an anaemia which was classified as microcytic and normochromic. Lymphopenia, eosinopenia and monocytopenia were also observed, possibly due to its handling and stress conditions.
The clinical chemistry presented low values for AST and creatinine, although this did not represent the existence of any pathologic context or disease with clinical significance. Forty Ross mole broilers, were used divided into 4 groups of 10 birds, and such groups have been submitted to the following treatments: T1- control feed without aflatoxin or sodium bentonite, T2- feed containing 5ppm of aflatoxin, T3- feed containing 5ppm of aflatoxin and 0.
Ali these treatments have been appiied from the l st to the 42nd day of lif e. Aspartate aminotransferase AST blood test. Association of ALT and the metabolic syndrome among Mexican children. The aim of this study was to determine the prevalence and associations between ALT elevations and MetS in normal-weight, overweight and obese Mexican children and adolescents, since data in Mexico is scarce. Body mass index BMI , waist circumference WC , percentage body fat, blood pressure, glucose, lipid profiles, ALT and aspartate aminotransferase AST were measured in , yo normal-weight, overweight and obese Mexicans from eight public schools.
Published by Elsevier Ltd. All rights reserved. AST safety analysis experience. The main approaches and results of design and beyond-design accidents analyses for the AST NHR, and the results of probabilistic safety assessments are considered. It is concluded that the AST possesses a high safety level in virtue of the development and realization in the design of self-protection, passivity and defence-in-depth principles.
Alanine transaminase ALT blood test. Changes in alt , ast and alp values of plasma and serum samples Blood samples were obtained from a total of 20 patients that presented with cases of liver malfunction at the Ebonyi State University Teaching Hospital, Abakaliki, Nigeria. The enzyme assays were carried out immediately upon sample collection and separation to obtain the baseline value BV , and thereafter at specified What is an AST Test?
AST aspartate aminotransferase is an enzyme that is Ast DyS also provides additional scientific output computed from the raw observational data. This value added currently includes: more accurate orbits computed with advanced dynamical and observational error model s; their uncertainty, as expressed by the covariance matrix formalism; ephemerides computed on request for each observer, with uncertainty; mean and proper orbital elements for this output, Ast DyS is the primary source worldwide ; statistical quality control, providing a rigorous observational error model.
All this is available with a sophisticated web interface, providing multiple search functions and online computations as well as complete orbital and residual files. There are several ways in which the A stDyS service could be expanded and improved in the next future, like the explicit classification of asteroids into asteroid families, the classification of resonant asteroids, and an updated self - consistent population model to be used, e.
In healthy volunteers treated with AZD, serum alanine aminotransferase ALT and aspartate aminotransferase AST activities were elevated without an increase in other markers for liver injury.
In subsequent in vitro studies, we observed increased expression of ALT 1 protein and mRNA in human hepatocytes after treatment with fenofibric acid. Ph AST : pharmacophore alignment search tool. We present a ligand-based virtual screening technique Ph AST for rapid hit and lead structure searching in large compound databases. Molecules are represented as strings encoding the distribution of pharmacophoric features on the molecular graph.
In contrast to other text-based methods using SMILES strings, we introduce a new form of text representation that describes the pharmacophore of molecules. This string representation opens the opportunity for revealing functional similarity between molecules by sequence alignment techniques in analogy to homology searching in protein or nucleic acid sequence databases. In a prospective application, Ph AST identified two novel inhibitors of 5-lipoxygenase product formation with minimal experimental effort.
This outcome demonstrates the applicability of Ph AST to drug discovery projects and provides an innovative concept of sequence-based compound screening with substantial scaffold hopping potential. The experimental setup, scope and preliminary results are presented in the paper. The European Ast RoMap project supported by the European Commission Seventh Framework Programme surveyed the state of the art of astrobiology in Europe and beyond and produced the first European roadmap for astrobiology research.
In the context of this roadmap, astrobiology is understood as the study of the origin, evolution, and distribution of life in the context of cosmic evolution; this includes habitability in the Solar System and beyond. The Ast RoMap Roadmap identifies five research topics, specifies several key scientific objectives for each topic, and suggests ways to achieve all the objectives.
Editorial ALT -J non-electronica. Full Text Available The ALT Executive Committee has discussed on a number of occasions the question of making ALT -J wholly available in electronic form on our Web site at present only the editorial and abstracts of papers appear, and even of turning it into a full-blown electronic journal.
I have gently but consistently opposed this move, on occasions to the intense irritation of some of my fellow members, and always at the risk of appearing to be a Luddite. Explicitly 'Who, if not we as learning technologists, should be in the forefront of the soon-to-happen electronic-journal revolution? I set out here my reasons for my continued resistance. Our Membership includes practitioners, researchers and policy makers with an interest in Learning Technology. Our community grows more diverse as Learning Technology has become recognised as a fundamental part of learning, teaching and assessment.
Our charitable objective is "to advance education through increasing, exploring and disseminating knowledge in t Full Text Available Seventy equines distributed in two experimental groups were used, G1 20 healthy equines, and G2 50 equines with colic. Blood samples were obtained by jugular vein puncture in ten different moments.
The variables aspartate aminotransferase AST , creatine kinase CK, and lactate dehydrogenase LDH were determined by spectrophotometric assay using specific reagents. Die Bauten waren bereits im All the designs represent enhanced safety reactor plants meeting the contemporary national requirements and international recommendations for nuclear plants of the new generation.
The main objectives for the advanced NHR development are considered. New design decisions and engineering improvements are described briefly.
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